Paliperidone-D4

CAT. No. P010011

CAS. No. 1020719-55-4

Paliperidone-d4 is a deuterated derivative of paliperidone, which is a medication used in the treatment of schizophrenia and schizoaffective disorder. Paliperidone is an antipsychotic drug that works by affecting the levels of neurotransmitters in the brain, particularly dopamine and serotonin.

Deuterium is an isotope of hydrogen that contains an extra neutron in its nucleus, making it heavier than the more common hydrogen isotope. The substitution of hydrogen atoms with deuterium in a molecule like paliperidone can sometimes alter the drug's pharmacokinetic properties, potentially affecting its absorption, distribution, metabolism, and excretion in the body. This can lead to differences in the drug's efficacy and safety profile compared to the non-deuterated version.

Paliperidone itself is the primary active metabolite of risperidone, another antipsychotic medication. It is available in various formulations, including an extended-release tablet (Invega Sustenna), which provides a long-acting form of the medication.

The addition of deuterium (a heavy isotope of hydrogen) to a molecule like paliperidone can sometimes affect its pharmacokinetics. Deuterium substitution can alter the way a drug is metabolized in the body, potentially leading to differences in its effectiveness and safety profile compared to the non-deuterated version.

The specific reasons for developing deuterated versions of drugs like paliperidone can vary. In some cases, it may be done to extend the drug's duration of action, reduce the frequency of dosing, or enhance its overall pharmacological properties.

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